Botulism: clinical features

Evidence-based neurology checklist on botulism: clinical features: Pathogenesis of botulism Botulism is caused by the exotoxins of Clostridium botulinum: toxins A-G The toxins act by presynaptic neuromuscular junction (NMJ) blockade They do this by inhibiting acetylcholine release This causes…

Pathogenesis of botulism

  • Botulism is caused by the exotoxins of Clostridium botulinum: toxins A-G
  • The toxins act by presynaptic neuromuscular junction (NMJ) blockade
  • They do this by inhibiting acetylcholine release
  • This causes neuromuscular paralysis

Infantile botulism: features

Other forms of botulism

Botulism weakness

Autonomic dysfunction: features

Symmetrical cranial neuropathies: features

Differential diagnosis

References

  1. Thajeb T, Chen Y-M, Dai D-F, Thajeb P. Botulism: a frequently forgotten old malady. Int J Gerontol 2007; 1:118-124.
  2. Sobel J. Botulism. Clin Infect Dis 2005; 41:1167-1173.
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