Ebola virus disease (EVD): clinical features

Evidence-based neurology checklist on ebola virus disease (evd): clinical features: Virology and pathology of EVD Ebola is an RNA filovirus Bats are its main reservoirs The virus is excreted in all body fluids The incubation period is 2-21 days: it is usually 4-10 days It demonstrates viral…

Virology and pathology of EVD

  • Ebola is an RNA filovirus
  • Bats are its main reservoirs
  • The virus is excreted in all body fluids
  • The incubation period is 2-21 days: it is usually 4-10 days
  • It demonstrates viral persistence: this causes relapse of infection
  • Patients with Niemann-Pick disease are resistant to the virus

Transmission

Neurological features

Magnetic resonance imaging (MRI)

Haemorrhagic features

Systemic features

Post Ebola syndrome

Differential diagnosis

References

  1. Billioux BJ, Smith B, Nath A. Neurological complications of Ebola virus infection. Neurotherapeutics 2016; 13:461-470. 
  2. Martínez MJ, Salim AM, Hurtado JC, Kilgore PE. Ebola virus infection: overview and update on prevention and treatment. Infect Dis Ther 2015; 4:365-390. 
  3. de Greslan T, Billhot M, Rousseau C, et al. Ebola virus-related encephalitis. Clin Infect Dis 2016; 63:1076-1078.
  4. Chertow DS, Nath A, Suffredini AF, et al. Severe meningoencephalitis in a case of Ebola virus disease: a case report. Ann Intern Med 2016; 165:301-304.
  5. Fischer WA 2nd, Uyeki TM, Tauxe RV. Ebola virus disease: what clinicians in the United States need to know. Am J Infect Control 2015; 43:788-793.
  6. And 7 more. Subscribe to see the full list

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