Familial mesial temporal lobe epilepsy (FMTLE)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Familial mesial temporal lobe epilepsy (FMTLE). This is caused by chromosome 4 gene mutations in some families. Fully referenced neurology checklist.

Genetics of FMTLE

  • This is caused by chromosome 4 gene mutations in some families
  • The transmission is complex: it is probably autosomal dominant
  • The onset is in adolescence or adult age
  • Some families have hippocampal sclerosis (HS)

Seizure types

Locked: subscribe to see this section.

Major features

Locked: subscribe to see this section.

Other features

Locked: subscribe to see this section.

Severe phenotype

Locked: subscribe to see this section.

Magnetic resonance imaging (MRI)

Locked: subscribe to see this section.

References

  1. Crompton DE, Scheffer IE, Taylor I, et al. Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain 2010; 133:3221-3231.
  2. Striano P, Gambardella A, Coppola A, et al. Familial mesial temporal lobe epilepsy (FMTLE): A clinical and genetic study of 15 Italian families. J Neurol 2008; 255:16-23.
  3. Harris RV, Oliver KL, Perucca P, et al. Familial mesial temporal lobe epilepsy: clinical spectrum and genetic evidence for a polygenic architecture. Ann Neurol 2023 (Online ahead of print).
  4. Hedera P, Blair MA, Andermann E, et al. Familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology 2007; 68:2107-2112. 
  5. Perucca P, Crompton DE, Bellows ST, et al. Familial mesial temporal lobe epilepsy and the borderland of déjà vu. Ann Neurol 2017; 82:166-176.
  6. And 1 more. Subscribe to see the full list

Related checklists

Loading...