Lyme neuroborreliosis: clinical features

Evidence-based neurology checklist on lyme neuroborreliosis: clinical features: Onset features Tick bite: this is recalled in 40% of cases Erythema migrans Lymphocytoma Lymphocytic meningitis Cranial neuropathies Peripheral nerve features Cerebral vasculitis Other features

Onset features

  • Tick bite: this is recalled in 40% of cases
  • Erythema migrans
  • Lymphocytoma

Lymphocytic meningitis

Cranial neuropathies

Peripheral nerve features

Cerebral vasculitis

Other features

References

  1. Mygland A, Ljosrad U, Fingerle V, Rupprecht T, Schmutzhard E, Steiner I. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 2010; 17:8-16.
  2. Prasad A, Sankar D. Overdiagnosis and overtreatment of Lyme neuroborreliosis are preventable. Postgrad Med J 1999; 75:650-656.
  3. Gu K, Boodman C, Orr P, Wuerz T. Early Lyme neuroborreliosis manifesting as brachial plexopathy and meningitis in Northwestern Ontario, Canada: a case report. Medicine (Baltimore) 2022; 101:e31576.
  4. Bajons D, Fröhlich R, Grandits W, Krstic M, Rauschka H, Katzenschlager R. Lyme neuroborreliosis: Progressive cerebral vasculitis responsive to cyclophosphamide. A case report and review of the literature. J Stroke Cerebrovasc Dis 2023 (Online ahead of print).
  5. Winter Y, Simon OJ, Spreer A, et al. Cerebral vasculitis as clinical manifestation of neuroborreliosis: pattern of vascular pathology and prognostic factors of outcome. Int J Stroke 2025; 20:205-214. 
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